1. Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.
2. fibronectins from different sources contribute differentially to specific aspects of angiogenesis.
3. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
4. we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 as the central mediators in these processes
5. FN is a fundamental component of the hematopoietic tissue and that the EIIIA exon may play a key role in modulating hematopiesis in conditions of bone marrow stress or diseases.
6. PD increased CKIP-1 and Nrf2 levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1
7. fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities
8. The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.
9. analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation
10. scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown.
11. The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 as opposed to fibronectin.
12. Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
13. These results suggest that the Rac1 regulation of the FN arrangement is involved in retinoic acid-induced cleft palate.
14. Fibrillar cellular fibronectin supports platelet adhesion, activation, aggregation and procoagulant activity via the interplay of a series of receptors i.e. integrins alpha5beta1 and alphaIIbbeta3, the GPIb-V-IX complex, GPVI and Toll-like receptor 4.
15. Fn1 synthesized by the neural crest mediated morphogenesis of the aortic arch artery and differentiation of neural crest cells into vascular smooth muscle cells by regulating Notch signaling.
16. These findings indicate an indispensable role for Fn in chronic liver fibrosis/cirrhosis.
17. Hypercholesterolemic mice deficient in extra domain A of fibronectin exhibit reduced cerebral thrombosis.
18. the epithelial interaction between fibronectin and beta1 integrin is important for ameloblast differentiation and enamel formation.
19. An (as yet unknown) integrin alpha5-dependent signal extrinsic to the pharyngeal endothelium mediates the formation of the 4th pharyngeal arch arteries through fibronectin.
20. TLR4 signaling contributes to EDA(+)-FN-mediated exacerbation of atherosclerosis.
21. 5-HT) inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation
22. This study demonstrated that the EIIIA domain of aFn mediates proliferation of OPCs, but not migration.
23. The DP-4 peptide activated Fn and enhanced cell adhesion activity
24. demonstrate the susceptibility of FN in the extracellular matrix to proteolysis and the resulting loss of cell adhesion due to the decrease of FN activity
25. fibronectin secretion has a role in mesothelial cells promotion of early ovarian cancer metastasis
26. These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin fibril extension.
27. Notch signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin EIIIA expression during valve morphogenesis
28. Regional differences in cell proliferation and fibronectin structure were dependent on both soluble fibronectin concentration and fibronectin-collagen type I interactions.
29. Data indicate that both fibronectin and VEGF then cooperate to stimulate blood vessel formation.
30. Silencing fibronectin expression produced similar effects as miR-378a-5p.
31. our data point to a potential role for the fibronectin-alpha5beta1 integrin interaction in promoting vascular remodeling during demyelinating disease
32. Fibronectin and integrin alpha5beta1 have critical roles in mouse embryogenesis
33. Fibronectin is essential for endogenous cardiac progenitor cell expansion and repair required for stabilization of cardiac function after myocardial infarction.
34. Loss of fibronectin negatively affects precardiac mesoderm.
35. Extra domain A-containing fibronectin is necessary for the development of nasal tissue fibrotic remodeling process in both murine and human allergic rhinitis.
36. cleavage by gingipains directly affects the biological activity of both fibronectin and tenascin-C in a manner that might lead to increased cell detachment and loss during periodontal disease.
37. FN and Wnt7a together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis.
38. RhoA activates NFAT by inducing a rise of [Ca(2+)]i in podocytes, which in turn contributes to fibronectin upregulation.
39. Fetal fibronectin activates MMP-1, MMP-9, and COX-2 in mesenchymal cells and causes preterm labor in mice.
40. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells.
41. Data indicate that beta3 integrin is required for Pyk2 cell surface localization and fibronectin accumulation.
42. analysis of force induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis
43. Data indicate that expression of fibronectin (FN) was significantly higher in primary macrophages than in a macrophage-like cell line, RAW264.7, suggesting that abundant FN might suppress the responsiveness in the primary macrophages.
44. Dataset suggests a possible role for fibronectin and its proteolytic fragments in venous thrombus resolution and identifies a novel N-terminal-derived 50 kDa fibronectin fragment that: contains the Vegf binding site.
45. This work defines fibronectin as a novel antiapoptotic factor for hepatocytes after acute liver injury, but demonstrates that fibronectin is not essential for subsequent hepatocyte proliferation.
46. By providing cell adhesive signals that can act with other self-renewal factors to maintain embryonic stem cell pluripotency, fibronectin is a necessary component of the self-renewal signaling pathway in culture.
47. Data indicate that peptide-based molecular probes capable of selectively discriminating fibronectin (Fn) fibers under different strain states.
48. Cellular fibronectin that contains the alternatively spliced extra domain A (EIIIA)promotes hepatic stellate cell motility but not differentiation into myofibroblasts.
49. Data suggest that fibronectin is a critical mediator for TGF-beta-specific production balance of 2 major proteoglycans, aggrecan and versican, during chondrogenesis.
50. Bacillus anthracis infection contribute to the formation of thrombi consisting of aggregated bacteria, vWF, shed SDC-1, fibrin, activated platelets and fibronectin.

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