This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its C-terminal. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

AA Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRV EECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKT NRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYS RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLD VVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFH NNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSC KGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQ SYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSG CNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWG GTLLWT

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.