Leptin (116-130) mouse [258276-95-8]

Biological Activity

Leptin (116-130) mouse is a synthetic leptin peptide fragment. Leptin (116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. Leptin (116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of Leptin (116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate.

Chemical Information

Molecular Weight	1560.73
Formula	C64H109N19O24S
CAS Number	258276-95-8
Solubility (25°C)	Water ≥ 50 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] P Grasso, et al. Diabetes. Inhibitory Effects of Leptin-Related Synthetic Peptide 116-130 on Food Intake and Body Weight Gain in Female C57BL/6J ob/ob Mice May Not Be Mediated by Peptide Activation of the Long Isoform of the Leptin Receptor