LAMP1 Antibody
Referencia OAEE00597
embalaje : 100tests(T100)
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for LAMP1 Antibody |
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| Predicted Species Reactivity | Human|Mouse|Non-human Primate |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | H4A3 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | Human PBMC |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 4 ul / test |
| Specificity | The mouse monoclonal antibody H4A3 recognizes CD107a, an approximately 100-120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane. |
| Formulation | PE |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 0.02% sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan PL, Lam KT, Peiris JS, Lau YL: Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. J Virol. 2010 May;84(9):4148-57. Yu CI, Gallegos M, Marches F, Zurawski G, Ramilo O, García-Sastre A, Banchereau J, Palucka AK: Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines. Blood. 2008 Nov 1;112(9):3671-8. Tomescu C, Chehimi J, Maino VC, Montaner LJ: NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement forIFN-mediated NK activation by plasmacytoid dendritic cells. J Immunol. 2007 Aug 15;179(4):2097-104. Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ: DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res. 2007 Feb 1;67(3):1317-25. Marcenaro S, Gallo F, Martini S, Santoro A, Griffiths GM, Aricó M, Moretta L, Pende D: Analysis of natural killer-cell function in familial hemophagocyticlymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4defect and discriminates between genetic subtypes of the disease. Blood. 2006 Oct 1;108(7):2316-23., Furuta K, Ikeda M, Nakayama Y, Nakamura K, Tanaka M, Hamasaki N, Himeno M, Hamilton SR, August JT: Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases. Am J Pathol. 2001 Aug;159(2):449-55. And many other. Mane SM, Marzella L, Bainton DF, Holt VK, Cha Y, Hildreth JE, August JT: Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 1989 Jan;268(1):360-78. Deetz CO, Hebbeler AM, Propp NA, Cairo C, Tikhonov I, Pauza CD: Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonistPam3Cys. Infect Immun. 2006 Aug;74(8):4505-11. |
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| Gene Symbol | LAMP1 |
| Gene Full Name | lysosomal associated membrane protein 1 |
| Alias Symbols | CD107 antigen-like family member A, CD107a, LAMP-1, LAMPA, LGP120, lysosome-associated membrane glycoprotein 1, lysosome-associated membrane protein 1. |
| NCBI Gene Id | 3916 |
| Protein Name | Lysosome-associated membrane glycoprotein 1 |
| Description of Target | Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. |
| Uniprot ID | P11279 |
| Protein Accession # | NP_005552.3 |
| Nucleotide Accession # | NM_005561.3 |
