ARP61222_P050-HRP | IRAK2 Antibody - C-terminal region

Datasheets/Manuals	Printable datasheet for anti-IRAK2 (ARP61222_P050-HRP) antibody

Product Info
Predicted Species Reactivity	Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Yeast
Product Format	Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Clonality	Polyclonal
Host	Rabbit
Conjugation	HRP: Horseradish Peroxidase
Application	WB
Reconstitution and Storage	All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Immunogen	The immunogen is a synthetic peptide directed towards the C terminal region of human IRAK2
Purification	Affinity Purified
Predicted Homology Based on Immunogen Sequence	Cow: 93%; Guinea Pig: 93%; Horse: 79%; Human: 100%; Mouse: 79%; Rabbit: 79%; Rat: 86%; Yeast: 83%
Peptide Sequence	Synthetic peptide located within the following region: SSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFG
Concentration	0.5 mg/ml
Blocking Peptide	For anti-IRAK2 (ARP61222_P050-HRP) antibody is Catalog # AAP61222 (Previous Catalog # AAPP47368)

Gene Symbol	IRAK2
Gene Full Name	Interleukin-1 receptor-associated kinase 2
Alias Symbols	IRAK-2
NCBI Gene Id	3656
Protein Name	Interleukin-1 receptor-associated kinase-like 2
Description of Target	IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
Uniprot ID	O43187
Protein Accession #	NP_001561
Nucleotide Accession #	NM_001570
Protein Size (# AA)	625
Molecular Weight	69kDa
Protein Interactions	TNFSF9; TRAF6; HSP90AA1; PSEN1; IRAK1; IL1R1; MYD88; UBC; TIRAP; SESTD1; ZC3H12C; ZC3H12A; FASTKD5; ADCK3; YTHDF1; TOLLIP; IRAK4; TARDBP; SARM1; SNRNP200; IRAK3; CDC37; IQSEC1; IQCB1; BAG3; STT3A; ARAF; TNFAIP3; MME; TICAM2; SMURF1; IRAK2; TLR4; SMAD2; HR

Protein interactions

Biological pathways

Name	# of Products
Activation of MAPK activity	317
I-kappaB kinase/NF-kappaB cascade	54
Inflammatory response	911
Innate immune response	905
Interleukin-1-mediated signaling pathway	31
JNK cascade	79
MyD88-dependent toll-like receptor signaling pathway	331
MyD88-independent toll-like receptor signaling pathway	288
Negative regulation of NF-kappaB transcription factor activity	94
Nucleotide-binding oligomerization domain containing signaling pathway	60
Positive regulation of NF-kappaB transcription factor activity	346
Regulation of cytokine-mediated signaling pathway	17
Stress-activated MAPK cascade	207
Toll signaling pathway	369
Toll-like receptor 1 signaling pathway	309
Toll-like receptor 2 signaling pathway	309
Toll-like receptor 3 signaling pathway	272
Toll-like receptor 4 signaling pathway	330

Biological process

Name	# of Products
Activation of MAPK activity	105
I-kappaB kinase/NF-kappaB cascade	37
Inflammatory response	339
Innate immune response	300
Interleukin-1-mediated signaling pathway	19
JNK cascade	53
Lipopolysaccharide-mediated signaling pathway	48
MyD88-dependent toll-like receptor signaling pathway	65
MyD88-independent toll-like receptor signaling pathway	56
Negative regulation of NF-kappaB transcription factor activity	49
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	36
Nucleotide-binding oligomerization domain containing signaling pathway	20
Positive regulation of NF-kappaB transcription factor activity	135
Protein phosphorylation	451
Regulation of cytokine-mediated signaling pathway	4
Response to interleukin-1	34
Signal transduction	1058
Stress-activated MAPK cascade	47
Toll signaling pathway	66
Toll-like receptor 1 signaling pathway	59
Toll-like receptor 2 signaling pathway	61
Toll-like receptor 3 signaling pathway	54
Toll-like receptor 4 signaling pathway	64
Toll-like receptor signaling pathway	71
TRIF-dependent toll-like receptor signaling pathway	53

Cellular components

Protein function

Name	# of Products
ATP binding	2814
Nucleotide binding	3928
Protein binding	12191
Protein heterodimerization activity	1132
Protein homodimerization activity	1852
Protein kinase activity	636
Transferase activity, transferring phosphorus-containing groups	127

IRAK2 ELISA Kit (Human) (OKCD01275)
Catalog #: OKCD01275

Application: ELISA-Sandwich

Kit Range: 0.78-50ng/mL

Sensitivity: < 0.27 ng/mL

IRAK2 Antibody - C-terminal region - HRP