Human PDPK1 Antibody : PE (Phospho-Ser241)
Referencia OAAQ00175-10tests
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Human PDPK1 Antibody : PE (Phospho-Ser241)
Human PDPK1 Antibody : PE (Phospho-Ser241) (OAAQ00175)
| Datasheets/Manuals | Printable datasheet for OAAQ00175 |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid 1X PBS with 0.2% BSA and 0.09% sodium azide |
| Clonality | Monoclonal |
| Clone | PDK1S241-F7 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | PE: Phycoerythrin |
| Application | FC |
| Reconstitution and Storage | Store at 2-8°C. Stable for one year from date of receipt. |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDK1 |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Ser241 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Peifer C and Alessi DR. (2008) ChemMedChem. 3: 1810-1838. Vanhaesebroeck B and Alessi DR. (2000) Biochemical Journal. 346: 561-576. |
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| Gene Symbol | PDPK1 |
| Gene Full Name | 3-phosphoinositide dependent protein kinase 1 |
| Alias Symbols | PDK1, PDPK2, PDPK2P, PRO0461 |
| NCBI Gene Id | 5170 |
| Protein Name | 3-phosphoinositide-dependent protein kinase 1 |
| Description of Target | PDK1 is a Ser/Thr kinase that is ubiquitously expressed throughout human tissues. PDK1 phosphorylates protein kinase B (PKB or Akt) at both Thr308 and Ser473 in vivo. PDK1 is active and phosphorylated in basal conditions, where it exists predominantly in the cytosol with a small fraction at the plasma membrane. This membrane association is likely mediated by PDK1 binding to phospholipids through its PH domain, which has been found to have strong affinity to specific phospholipids. PDK1 is a master regulator of at least 23 related protein kinases, and more than 50% of all human cancers show significant overstimulation of the PDK1 pathway. Most small-molecule inhibitors of PDK1 target the ATP binding site. |
| Uniprot ID | O15530 |
| Protein Accession # | NP_001248745.1 |
| Nucleotide Accession # | NM_001261816.1 |
