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> Her2 (ERBB2) Human Gene Knockout Kit (CRISPR)

Her2 (ERBB2) Human Gene Knockout Kit (CRISPR)

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Her2 (ERBB2) Human Gene Knockout Kit (CRISPR)

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SKU
KN212583RB
ERBB2 - human gene knockout kit via CRISPR, HDR mediated
 

Other products for "Her2 or NM_001005862"

Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Her2
Locus ID 2064
Components

KN212583G1, Her2 gRNA vector 1 in pCas-Guide CRISPR vector

KN212583G2, Her2 gRNA vector 2 in pCas-Guide CRISPR vector

KN212583RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001005862, NM_001289936, NM_001289937, NM_001289938, NM_004448, NR_110535
UniProt ID P04626
Synonyms CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. provided by RefSeq, Jul 2008
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Product Manuals
FAQs
    FAQ for CRISPR Products
SDS
SKU Description Size
GA101441 ERBB2 CRISPRa kit - CRISPR gene activation of human erb-b2 receptor tyrosine kinase 2 1 kit
KN212583 ERBB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN212583BN ERBB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN212583LP ERBB2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN412583 ERBB2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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