Heparan Sulfate [9050-30-0]
Referencia NB-64-09231-5mg
embalaje : 5mg
Marca : Neo Biotech
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Teléfono : +1 850 650 7790
Heparan Sulfate
Catalog No. T19355 Copy Product Info
Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Heparan Sulfate
Copy Product InfoHeparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Cas No. 9050-30-0
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins. |
| Targets&IC50 | MCF-10A cells (AR-induced mitogenesis):2 μg/mL, RBD:0.02 μg/mL |
| In vitro | METHODS: Breast cancer cells MDA-MB231 were treated with Heparan sulfate (20 µg/mL) for 24 h and detected by Fluorescence microscopy. RESULTS: Cell spreading was enhanced and the average spreading cell area approximately doubled in the presence of Heparan sulfate. Exogenous Heparan sulfate blocked cell invasion and matrix degradation. [1] |
| In vivo | METHODS: To assay anti-tumor activity in vivo, Heparan sulfate (0.8 mg/kg) was administered to SCID-hu mice injected with bone marrow aspirates from myeloma patients twice daily, once intraperitoneally and once subcutaneously, for four weeks. RESULTS: Treatment with Heparan sulfate significantly inhibited primary tumor growth in a human severe combined immunodeficiency (SCID-hu) myeloma model. [2] |
| Molecular Weight | 593.47(monomer) |
| Formula | C12H19NO20S3 (monomer) |
| Cas No. | 9050-30-0 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Insoluble  H2O: 100 mg/mL, Sonication is recommended. |
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