FGFR2 Capture Antibody
Referencia OAOA21767
embalaje : 100µg
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
FGFR2 Capture Antibody (OAOA21767)
| Datasheets/Manuals | Printable datasheet for FGFR2 Capture Antibody (OAOA21767) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Product Format | Stored in PBS (pH 7.4) containing 0.05% sodium azide and up to 5% trehalose |
| Clonality | Monoclonal |
| Clone | OTI3F8 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | MlpxA |
| Additional Information | Matched ELISA Pair: OAOA22208 |
| Reconstitution and Storage | -20°C |
| Immunogen | Full length human recombinant protein of human FGFR2 (NM_000141) produced in HEK293T cell. |
| Concentration | 0.5 mg/ml |
| Dilution | 1:100 - 1:1000 |
| Description | FGFR2 mouse monoclonal capture antibody, validated for Luminex assays |
| Gene Symbol | FGFR2 |
|---|---|
| Gene Full Name | fibroblast growth factor receptor 2 |
| Alias Symbols | bacteria-expressed kinase, BBDS, BEK, BEK fibroblast growth factor receptor, BFR-1, CD332, CEK3, CFD1, ECT1, fibroblast growth factor receptor 2, JWS, K-SAM, keratinocyte growth factor receptor, KGFR, protein tyrosine kinase, receptor like 14, TK14, TK25. |
| NCBI Gene Id | 2263 |
| Protein Name | Fibroblast growth factor receptor 2|Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1, mRNA |
| Description of Target | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. |
| Uniprot ID | P21802 |
| Protein Accession # | NP_000132 |
| Nucleotide Accession # | https://www.ncbi.nlm.nih.gov/nuccore/NM_000141 |
