EIF3F Antibody
Referencia OAED00076
embalaje : 50ug
Marca : Aviva Systems Biology
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Teléfono : +1 850 650 7790
EIF3F Antibody (OAED00076)
| Datasheets/Manuals | Printable datasheet for EIF3F Antibody (OAED00076) |
|---|
| Predicted Species Reactivity | Bovine|Dog|Guinea Pig|Hamster|Human|Monkey|Mouse|Porcine|Rabbit|Rat|Sheep |
|---|---|
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | Immunocytochemistry|Western blot |
| Reconstitution and Storage | Long Term Storage : -20C |
| Immunogen | Synthetic peptide corresponding to a portion of rat eIF2-alpha. |
| Specificity | Recognizes human, mouse, rat, bovine, dog, guinea pig, hamster, monkey, pig, rabbit and sheep eIF2-alpha. Detects a band of ~36kDa by Western blot. |
| Formulation | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Purity | Immunoaffinity purified. |
| Application Info | Immunocytochemistry Immunohistochemistry (paraffin sections) Western Blot (1μg/ml, ECL) Optimal conditions must be determined individually for each application. |
| Reference | Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation: L. Brown, et al. ; Am. J. Physiol. Endocrinol. Metab. 297, E638 (2009), Application(s): WB using sheep tissue, Abstract; Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules: P. Anderson, et al. ; Mol. Biol. Cell 13, 195 (2002), Application(s): ICC, WB using human samples, Abstract; PERK mediates cell-cycle exit during the mammalian unfolded protein response: J.A. Diehl, et al. ; PNAS 97, 12625 (2000), Application(s): WB using mouse samples, Abstract; |
|---|---|
| Gene Symbol | Eif2s1 |
| Gene Full Name | eukaryotic translation initiation factor 2 subunit alpha |
| Alias Symbols | EIF-2A;eIF-2-alpha;EIF-2alpha;eukaryotic translation initiation factor 2 subunit 1;eukaryotic translation initiation factor 2 subunit 1 alpha;Eukaryotic translation initiation factor 2 subunit alpha. |
| NCBI Gene Id | 54318 |
| Protein Name | Eukaryotic translation initiation factor 2 subunit 1 |
| Description of Target | Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Uniprot ID | P68101 |
| Protein Accession # | NP_003745.1 |
| Nucleotide Accession # | NM_003754.2 |
