Quimigen Portugal > DNMT1 Antibody
DNMT1 Antibody
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DNMT1 Antibody (OAEB01589)
| Datasheets/Manuals | Printable datasheet for DNMT1 Antibody (OAEB01589) |
|---|
| Predicted Species Reactivity | Bovine|Dog|Human|Mouse|Porcine|Rat |
|---|---|
| Product Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Clonality | Polyclonal |
| Host | Goat |
| Application | ELISA|IHC|WB |
| Reconstitution and Storage | -20°C |
| Immunogen | DNMT1 |
| Purification | Ammonium Sulfate Precipitated; Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Human, Mouse, Rat, Dog, Cow, Pig |
| Peptide Sequence | C-RFESPPKTQPTEDN |
| Concentration | 0.5 mg/ml |
| Intended Use | For research use only. |
| Application Info | P-ELISA: Antibody detection limit dilution 1:32000 WB: Approx 170kDa band observed in lysates of cell line Jurkat (calculated MW of 183kDa according to NP_001370.1). Recommended concentration: 0.5-1.5ug/ml. IHC: In paraffin embedded Human Kidney shows nuclear staining in PCT. Recommended concentration, 3-6ug/ml. |
| Reference | * Dion V, Lin Y, Hubert L Jr, Waterland RA, Wilson JH.; Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.; Hum Mol Genet. 2008 May 1;17(9):1306-17. Epub 2008 Feb 5.; Pubmed 18252747 |
|---|---|
| Gene Symbol | Dnmt1|DNMT1 |
| Gene Full Name | DNA methyltransferase (cytosine-5) 1|DNA methyltransferase 1 |
| Alias Symbols | ADCADN, AIM, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5-)-methyltransferase 1, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase (cytosine-5) 1, DNA methyltransferase HsaI, DNA methyltransferase I, DNA methyltransferase MmuI, DNA MTase HsaI, DNA MTase MmuI, DNA MTase RnoIP, DNMT, Dnmt1o, HSN1E, m.HsaI, m.MmuI, m.RnoIP, MCMT, Met-1, Met1, MommeD, MommeD2, MTa, MTase. |
| NCBI Gene Id | 13433|1786|84350 |
| Protein Name | DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] |
| Uniprot ID | P26358 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_001370.1 |
| Molecular Weight | 183 |
Protein interactions
| Name | # of Products |
|---|---|
| AKT1 | 428 |
| BAZ2A | 16 |
| CBX1 | 117 |
| CHEK1 | 85 |
| CSNK2B | 317 |
| DAXX | 194 |
| DMAP1 | 82 |
| DNMT3A | 38 |
| DNMT3B | 93 |
| DYNLL | 10 |
| EED | 123 |
| EHMT2 | 146 |
| EZH2 | 171 |
| GSK3B | 566 |
| HDAC1 | 928 |
| HDAC2 | 549 |
| HELLS | 12 |
| HSPA4 | 423 |
| HSPA5 | 264 |
| KAT5 | 318 |
| PCNA | 402 |
| RAD9A | 68 |
| RB1 | 474 |
| RPS6KA6 | 59 |
| SETD7 | 40 |
| SMARCA5 | 76 |
| SNRPG | 24 |
| SP1 | 551 |
| SP3 | 46 |
| STAT3 | 275 |
| SUV39H1 | 85 |
| SUZ12 | 76 |
| TCF3 | 151 |
| TP53 | 1010 |
| TRIM27 | 111 |
| UBC | 7030 |
| UHRF1 | 28 |
| USP7 | 233 |
| WT1 | 56 |
| YWHAQ | 716 |
Biological pathways
| Name | # of Products |
|---|---|
| Chromatin modification | 179 |
| Maintenance of DNA methylation | 15 |
| Negative regulation of histone H3-K9 methylation | 16 |
| Negative regulation of transcription from RNA polymerase II promoter | 682 |
| Positive regulation of gene expression | 74 |
| Positive regulation of histone H3-K4 methylation | 23 |
| Transcription, DNA-dependent | 3394 |
Biological process
| Name | # of Products |
|---|---|
| C-5 methylation of cytosine | 7 |
| Cellular response to amino acid stimulus | 46 |
| Chromatin modification | 199 |
| DNA methylation | 14 |
| Gene silencing | 7 |
| Maintenance of DNA methylation | 5 |
| Negative regulation of histone H3-K9 methylation | 5 |
| Negative regulation of transcription from RNA polymerase II promoter | 574 |
| Positive regulation of gene expression | 160 |
| Positive regulation of histone H3-K4 methylation | 7 |
| Regulation of cell proliferation | 128 |
Cellular components
| Name | # of Products |
|---|---|
| Centromeric heterochromatin | 9 |
| Nucleus | 4914 |
| Replication fork | 9 |
Protein function
| Name | # of Products |
|---|---|
| DNA (cytosine-5-)-methyltransferase activity | 17 |
| DNA binding | 3958 |
| DNA-methyltransferase activity | 22 |
| Metal ion binding | 5514 |
| Protein binding | 12191 |
| Transcription factor binding | 934 |
| Transferase activity | 1042 |
| Zinc ion binding | 3721 |
Diseases
| Name | # of Products |
|---|---|
| Disease mutation | 5332 |
| Neuropathy | 162 |
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Dnmt1 Antibody - N-terminal region (ARP37033_P050)Catalog #: ARP37033_P050Species Tested: MouseApplication: WBFormat: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. -
DNMT1 Antibody (Phospho-Ser714) (OAAB01898)Catalog #: OAAB01898Application: DBFormat: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. -
Dnmt1 Antibody - C-terminal region (Phospho-S1602) (OAAB07265)Catalog #: OAAB07265Application: FC,WBFormat: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. -
Dnmt1 Antibody (Phospho-Ser1105) (OAAB16265)Catalog #: OAAB16265Application: DBFormat: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. -



