Dapagliflozin ((2S)-1,2-propanediol, hydrate)
Referencia M5551-50mg
embalaje : 50mg
Marca : AbMole Bioscience
Synonym:
BMS-512148 (2S)-1,2-propanediol, hydrate
Quality Control & Documentation
Biological Activity
Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate.
Chemical Information
Molecular Weight | 502.98 |
Formula | C24H35ClO9 |
CAS Number | 960404-48-2 |
Solubility (25°C) | 10 mM in DMSO |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Ghosh RK, et al. J Clin Pharmacol. SGLT2 inhibitors: a new emerging therapeutic class in the treatment of type 2 diabetes mellitus.