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D-Galactose [59-23-4]

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Referencia NB-64-00765-500mg

embalaje : 500mg

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : Neo Biotech

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Contact local distributor :

Teléfono : +1 850 650 7790

D-Galactose (Synonyms: D-Galactopyranose, D-(+)-Galactose, Alpha-D-galactose)

Catalog No. T0591 Copy Product Info

Purity: 99.96%

D-Galactose is a naturally occurring hexose and a C-4 epimer of glucose. It can combine with glucose to form lactose and is commonly used to establish animal models of aging.

D-Galactose

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Synonyms D-Galactopyranose, D-(+)-Galactose, Alpha-D-galactose

D-Galactose is a naturally occurring hexose and a C-4 epimer of glucose. It can combine with glucose to form lactose and is commonly used to establish animal models of aging.

Cas No. 59-23-4

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	D-Galactose is a naturally occurring hexose and a C-4 epimer of glucose. It can combine with glucose to form lactose and is commonly used to establish animal models of aging.
In vitro	Galactose is important for the survival and virulence of bacteria. Galactose is utilized by the Leloir pathway in Escherichia coli. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation[1].
In vivo	Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. Moreover, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents[2]. D-galactose given by oral route leads to cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-field test in the 4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of d-gal administration[3].
Disease Modeling Protocol	Aging model Modeling Mechanism： D-Galactose catalyzes the production of galactitol via aldose reductase, causing osmotic pressure damage to cells. It also induces increased vascular permeability, abnormal collagen metabolism, and hypogonadotropic endocrine disorders, mimicking the decline in tissue function associated with aging. Related Products： D-Galactose (T0591) Modeling Method： Experimental Subject： Rats, Sprague-Dawley, Male, 180–280 g Dosage and Administration Route： 10%-50% weight percentage D-galactose, Mixed basal diet, Ad libitum feeding Dosing Frequency and Duration Model： Continuous feeding, 3 consecutive weeks Validation： ⁱ²⁵I-albumin vascular permeability (TBIR values in tissues such as the eye and kidney) was significantly increased; collagen solubility in granulation tissue reached 29%-35.8%; plasma galactose increased by 2.5-11.5 times, and testosterone levels decreased; tissue galactitol content was 135 times that of the control group. Precautions： References：Chang K,et,al. Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. J Clin Invest. 1987 Feb;79(2):367-73.
Synonyms	D-Galactopyranose, D-(+)-Galactose, Alpha-D-galactose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	59-23-4
Smiles	[C@@H]([C@@H]([C@H](C=O)O)O)([C@@H](CO)O)O
Relative Density.	1.5 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 66 mg/mL (366.34 mM), Sonication is recommended.

DMSO: 86.6 mg/mL (480.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (18.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.