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> Anti-FGFR2 Antibody (6X88)

Anti-FGFR2 Antibody (6X88)

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Anti-FGFR2 Antibody (6X88)

(Synonyms: TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS) Copy Product Info

Synonyms: TK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS

Catalog No. TMAY-01228 Copy Product Info
Anti-FGFR2 Antibody (6X88) is a Mouse antibody targeting FGFR2. Anti-FGFR2 Antibody (6X88) can be used in ELISA(Cap).
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-FGFR2 Antibody (6X88) is a Mouse antibody targeting FGFR2. Anti-FGFR2 Antibody (6X88) can be used in ELISA(Cap).
SynonymsTK25, TK14, K-SAM, KGFR, JWS, fibroblast growth factor receptor 2, FGFR2 α(IIIb), ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Ig Type
Mouse IgG1
Clone
6X88
Reactivity
Human
Specificity
Human FGFR2
Application
ELISA(Cap)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis product is a recombinant monoclonal antibody expressed from HEK293 cells.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundFGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human FGFR2 / CD332 Protein (TMPY-01228)
Antigen Species
Human
Biology Area
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Keywords

TK-25TK-14TK 25TK 14ECT-1ECT 1CFD-1CFD 1CEK-3CEK 3CD-332CD 332BFR1BFR 1
Related Tags: Anti-FGFR2 Antibody (6X88) chemical structure