Application

IF

IHC-Fr

IHC-P

WB

Recommended DoseAntibody TypeHost SpeciesRabbitSubcellular LocalizationCell junction, tight junction. Cell membrane; Multi-pass membrane protein.Tissue SpecificityExpressed in right lung and 192 other cell types or tissuesConstructionPolyclonal AntibodyPurificationProtein A purifiedAppearanceLiquidFormulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.Concentration1 mg/mLResearch BackgroundThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008] Antigen Details

Immunogen	KLH conjugated synthetic peptide: human claudin 5
Antigen Species	Human
Gene Name	CLDN5
Gene ID	7122
Protein Name	Claudin-5
Uniprot ID	O00501
Biology Area	Tight Junctions
Function	Plays a major role in tight junction-specific obliteration of the intercellular space.

Chemical Properties

Molecular Weight

Theoretical: 24 kDa. Actual: 30 kDa.

Stability & Storage

Stability & Storage	Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
Transport	Shipping with blue ice.