Anti-BCL-W Polyclonal Antibody
Referencia OAAI00633
embalaje : 100ug
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
Anti-BCL-W Polyclonal Antibody (OAAI00633)
| Datasheets/Manuals | Printable datasheet for Anti-BCL-W Polyclonal Antibody (OAAI00633) |
|---|
| Predicted Species Reactivity | Bovine|Canis|Chicken|Human|Mouse|Rat |
|---|---|
| Product Format | Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Application | ELISA, FC, IHC, IP, WB |
| Additional Information | Background: BCL-w is a member of the Bcl-2 family. The gene codes for a 21 kDa protein which is essential for the regulation of cellular survival, and that is up-regulated in different human tumors, such as gastric and colorectal carcinomas. Inhibition of AKT activity may promote apoptosis through the down-regulation of Bcl-w protein and the consequential reduction in interaction of Bcl-w with pro-apoptotic members of the Bcl-2 family. |
| :: | Positive Control: Breast carcinoma |
| :: | Cellular Location: Mitochondria outer membrane. Nucleus membrane |
| Reconstitution and Storage | The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. |
| Immunogen | A synthetic peptide derived from N-terminus of human BCL-W protein. This sequence is identical among human, rat and mouse origins. |
| Purification | Affinity Purified |
| Concentration | 100ug/200ul |
| Specificity | BCL2L2 |
| Formulation | This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Application Info | WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested |
| Reference | Gibson,L., Bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene 13 (4), 665-675 (1996) |
|---|---|
| Gene Symbol | BCL2L2 |
| Gene Full Name | BCL2 like 2 |
| Alias Symbols | apoptosis regulator BCL-W;BCL2-L-2;bcl-2-like protein 2;BCLW;BCL-W;PPP1R51;protein phosphatase 1, regulatory subunit 51. |
| NCBI Gene Id | 599 |
| Description of Target | BCL-w is a member of the Bcl-2 family. The gene codes for a 21 kDa protein which is essential for the regulation of cellular survival, and that is up-regulated in different Human tumors, such as gastric and colorectal carcinomas. Inhibition of AKT activity may promote apoptosis throμgh the down-regulation of Bcl-w protein and the consequential reduction in interaction of Bcl-w with pro-apoptotic members of the Bcl-2 family. |
| Uniprot ID | Q92843 |
| Molecular Weight | 21 |
