| Short Description : | Mouse monoclonal anti-MDR1 P-gp for use in FC, IHC-F, IHC-P and WB in Human and Chinese Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC/IHC-F/IHC-P/WB |
| Host: | Mouse |
| Reactivity: | Human/Chinese Hamster |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | JSB-1 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 100 Mu g/mL |
| Dilution Range: | FC 1:10IHC-FIHC-P 1:20WB |
| Formulation: | PBS with 0.1% BSA and 0.02% sodium azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
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| Tissue Specificity | Expressed in small intestine. Expressed in liver, kidney and brain. |
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1Atp-Binding Cassette Sub-Family B Member 1Multidrug Resistance Protein 1P-Glycoprotein 1Phospholipid Transporter Abcb1Cd Antigen Cd243 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmAbcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Dependent Translocase Abcb1 antibodyAnti-Atp-Binding Cassette Sub-Family B Member 1 antibodyAnti-Multidrug Resistance Protein 1 antibodyAnti-P-Glycoprotein 1 antibodyAnti-Phospholipid Transporter Abcb1 antibodyAnti-Cd Antigen Cd243 antibodyAnti-ABCB1 antibodyAnti-MDR1 antibodyAnti-PGY1 antibody |
Information sourced from Uniprot.org