Anakinra
Referencia M10139-10mg
embalaje : 10mg
Marca : AbMole Bioscience
Raleukin; AMG-719
Quality Control & Documentation
Biological Activity
Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. Anakinra is the first biological agent to block the pro-inflammatory effects. In vivo, combined Etanercept (5 mg/kg, ip) and Anakinra (100 mg/kg, ip. daily for 7 days) substantially improves marginal mass human islet engraftment in immunodeficient mice. Anakinra enhances tumor growth inhibition in mice receiving peptide vaccination and β-(1-3),(1-6)-D-glucan.
Product Citations
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Cell Biosci. 2022 Jun 17;12(1):90.
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
Anakinra purchased from AbMole
Chemical Information
Molecular Weight | 509.56 |
Formula | C20H23N5O7S2 |
CAS Number | 143090-92-0 |
Storage | 2-8°C, do not freeze |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] B Naziruddin, et al. Am J Transplant. Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL-1β and TNFα
[2] M McCall, et al. Am J Transplant. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice
[3] Ulf Harnack, et al. Anticancer Res. IL-1 receptor antagonist anakinra enhances tumour growth inhibition in mice receiving peptide vaccination and beta-(1-3),(1-6)-D-glucan