7-Dehydrocholesterol [434-16-2]

Biological Activity

7-Dehydrocholesterol (7-DHC) is a metabolic intermediate in cholesterol synthesis as well as an unsaturated sterol whose conjugated double bond on the sterol's B ring allows 7-DHC to take up free radicals, thereby counteracting the ability of free radicals to trigger lipid oxidation and iron death.

Chemical Information

Molecular Weight	384.64
Formula	C27H44O
CAS Number	434-16-2
Form	Solid
Solubility (25°C)	Ethanol 16.67 mg/mL DMSO 5 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Xiao-Jing Guo, et al. Front Microbiol. Compartmentalized Reconstitution of Post- s qualene Pathway for 7-Dehydrocholesterol Overproduction in Saccharomyces cerevisiae

[2] Jan Klouda, et al. Talanta. Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis

[3] Tae-Kang Kim, et al. Molecules. Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey

[4] Jun Xiao, et al. Immunity. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

[5] Malgorzata JM Nowaczyk, et al. Smith-Lemli-Opitz Syndrome