Xanthan Gum, USP/EP/FCC

Xanthan gum is an anionic polysaccharide composed of a β-(1→4)-D-glucopyranose glucan backbone with side chains of (1→3)-α-D-mannopyranose-(2→1)-β-D-glucuronic acid-(4→1)-β-D-mannopyranose on alternating residues. Approximately half of the terminal mannose residues are 4,6-pyruvated while most of the inner mannose residues are 6-acetylated. Its properties make it a useful matrix component for drug delivery systems. It forms stable drug suspensions in aqueous media and soft gels with locust bean gum or guar gum. Xanthan gum mimics the texture of lipids and is used as a control in experiments where signaling pathways initiated by consumption of lipid-containing reagents are investigated in mice.

CAS No:
11138-66-2

Purity:
91-108% (Assay)

Appearance:
Light yellow to light reddish yellow crystals

Viscosity:
1400-1600mPas

Elemental Analysis (Theoretical):
≤1.5% (Nitrogen)

Heavy Metals:
≤�20mg/kg

Arsenic:
≤�2mg/kg

Lead:
≤�2mg/kg

Mercury:
≤�1mg/kg

Cadmium:
≤�1mg/kg

pH:
6-8

Mould and Yeast:
≤50cfu/g

Loss on Drying:
≤12%

Residual Solvents:
Isopropyl alcohol: ≤500mg/kg

Coliform Organisms:
Negative/25g

E. coli:
Negative/25g

Microbial Count:
≤1000cfu/g (Total plate count)

Pseudomonas aeruginosa:
Negative/g

Salmonella:
Negative/25g

Staphylococcus aureus:
Negative/g

Particle Size:
100% through 60 mesh �
95% through 80 mesh

Organic Volatile Impurities:
Conforms to USP test

Related Substances:
Pyruvic acid: ≥1.5%

Ash:
6.5-16.0%

Other polysaccharides:
Conforms EP test

Powder color:
60

B. cereus:
Negative/g

Enterococcus faecalis:
Negative/g

Xanthomonas campestris:
Negative/g

Factor Viscosity:
1.02-1.45

Pyruvic acid:
≥1.5%

Storage and Stability:
Store at -20°C. Stable for 6 months after receipt. Hygroscopic. Store under inert gas (e.g. Argon).

Meets or exceeds USP/EP/FCC specifications