TNF alpha (AP)

Referencia MBS6248365-5x0,1mL

embalaje : 5x0.1mL

Marca : MyBiosource

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Alpha (TNF) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6248365

MBS6248365 is an antibody targeting TNF. Also known as TNF alpha (AP). Reactive in Bovine, Sheep. Host: Mouse. More details

Product Overview

Online Datasheet in PDF
Product Name
TNF alpha, Monoclonal Antibody
Full Product Name
TNF alpha (AP)
Product Gene Name
anti-TNF antibody
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
VPM61
Host
Mouse
Species Reactivity
Bovine, Sheep
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by Protein A Affinity Chromatography
Specificity
Recognizes sheep TNF alpha. Species Crossreactivity: bovine.
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Molecular Weight
25,536 Da
3D Structure
ModBase 3D Structure for P23383
Immunogen
Recombinant protein corresponding to sheep TNF alpha.
Conjugate
AP

Product Categories/Family for anti-TNF antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-TNF antibody
Immunohistochemistry (IHC), Western Blot (WB)

Testing Data of anti-TNF antibody

Intracellular staining of ovine TNF-alpha transfected CHO cells using at a dilution of 1:200 with a secondary Rabbit anti Mouse IgG conjugated to R-PE.
Mouse Anti-TNF Monoclonal Antibody – Cat# MBS6248365

Product References and Citations for anti-TNF antibody

1. Vilmos, P. et al. (1996) Phylogenetically concerved epitopes of leukocyte antigens. Vet. Immunology and Immunopathology 52:415-426. 2. Green, I.R. et al. (1993) Expression and characterization of bioactive recombinant ovine TNF-alpha: some species specificity in cytotoxic response to TNF. Cytokine 5:213-223.

Other Notes

Small volumes of anti-TNF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNF. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor
NCBI Official Symbol
TNF
NCBI Official Synonym Symbols
TNF-alpha
UniProt Protein Name
Tumor necrosis factor
UniProt Synonym Protein Names
Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
Protein Family
Tumor necrosis factor
UniProt Gene Name
TNF
UniProt Synonym Gene Names
TNFA; TNFSF2; TNF-a; NTF; ICD1; ICD2
UniProt Entry Name
TNFA_SHEEP
NCBI Protein Information
tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2

UniProt Comments for TNF

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNF antibody

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Diseases associated with anti-TNF antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >90724 publications with TNF and Necrosis
 Inflammation Antibodies  >32770 publications with TNF and Inflammation
 Vascular Diseases Antibodies  >7574 publications with TNF and Vascular Diseases
 Lung Diseases Antibodies  >6751 publications with TNF and Lung Diseases
 Liver Diseases Antibodies  >5155 publications with TNF and Liver Diseases
 Insulin Resistance Antibodies  >2518 publications with TNF and Insulin Resistance
 Fibrosis Antibodies  >2488 publications with TNF and Fibrosis
 Atherosclerosis Antibodies  >2411 publications with TNF and Atherosclerosis
 Colitis Antibodies  >2408 publications with TNF and Colitis
 Pain Antibodies  >2277 publications with TNF and Pain

Organs/Tissues associated with anti-TNF antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >7578 publications with TNF and Bone