TMEM173 Detection Antibody
Referencia OAOA22067
embalaje : 50µg
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
TMEM173 Detection Antibody : Biotin (OAOA22067)
| Datasheets/Manuals | Printable datasheet for TMEM173 Detection Antibody : Biotin (OAOA22067) |
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| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Stored in PBS (pH 7.4) with 0.05% sodium azide, 10mg/ml BSA, 50% glycerol |
| Clonality | Monoclonal |
| Clone | OTI1G5 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | Biotin |
| Application | MlpxA |
| Additional Information | Matched ELISA Pair: OAOA21610 |
| Reconstitution and Storage | -20°C |
| Immunogen | Full length human recombinant protein of human TMEM173(NP_938023) produced in HEK293T cell. |
| Concentration | 0.5 mg/ml |
| Dilution | 1:250 - 1:1000 |
| Description | TMEM173 biotinylated mouse monoclonal detection antibody, validated for Luminex assays |
| Gene Symbol | STING1 |
|---|---|
| Gene Full Name | stimulator of interferon response cGAMP interactor 1 |
| Alias Symbols | endoplasmic reticulum IFN stimulator, endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, MITA, mitochondrial mediator of IRF3 activation, MPYS, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, NET23, SAVI, stimulator of interferon genes protein, stimulator of interferon protein, STING, STING-beta, TMEM173, transmembrane protein 173. |
| NCBI Gene Id | 340061 |
| Protein Name | Homo sapiens transmembrane protein 173 (TMEM173), transcript variant 1, mRNA|Stimulator of interferon genes protein |
| Description of Target | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). |
| Uniprot ID | Q86WV6 |
| Protein Accession # | NP_938023 |
| Nucleotide Accession # | https://www.ncbi.nlm.nih.gov/nuccore/NM_198282 |
