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> TFE3 Rabbit Monoclonal Antibody [Clone ID: MRQ-37]

TFE3 Rabbit Monoclonal Antibody [Clone ID: MRQ-37]

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Referencia TA327744

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TFE3 Rabbit Monoclonal Antibody [Clone ID: MRQ-37]

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SKU
TA327744
Rabbit Monoclonal TFE3 Antibody
Size:
1 ml
Conjugation:
Unconjugated
 

View other "TFE3 or NM_006521" antibodies

Specifications
Product Data
Clone Name MRQ-37
Application IHC
Recommended Dilution IHC: 1:50 - 1:200
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Monoclonal
Buffer This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name transcription factor binding to IGHM enhancer 3
Database Link
Synonyms bHLHe33; RCCP2; RCCX1; TFEA
Note Xp11 translocation renal cell carcinoma (RCC) is a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus. Xp11 translocation RCC represents the most common type of RCC in children, but is less frequent on a percentage basis in adults. Morphologically, the neoplasm frequently shows papillary architecture and clear cytoplasm, and frequently has associated psammoma bodies. Immunohistochemically, the neoplasm under-expresses epithelial markers such as cytokeratin and epithelial membrane antigen compared with typical RCC. The most sensitive and specific immunohistochemical marker for the Xp11 translocation RCC is nuclear labeling of TFE3 protein, which reflects over-expression of the resulting fusion proteins relative to TFE3. Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma which affects predominantly young patients, often in the extremities.ASPS has the specific molecular translocation der(17)t(X;17)(p11.2;q25), which fuses the TFE3 transcription factor gene at 17q25 to ASPL, a gene at 17q25 to form a fusion transcript of ASPL-TFE3. The diagnosis of ASPS can be problematic due to histologic overlap with other tumors, particularly in small biopsies, as well as when the detection of a metastasis is prior to identification of a primary, or when presenting at unusual primary sites such as bone. Moreover, there has previously been a lack of specific diagnostic markers. The differential diagnoses include, in particular, paraganglioma, granular cell tumor, metastatic renal cell carcinoma, hepatocellular carcinoma, melanoma, and adrenal cortical carcinoma. Carcinomas can be separated by the expression of cytokeratins. Paraganglioma shows very strong positivity with anti-synaptophysin. Melanomas can be distinguished by strong positivity with antibodies against HMB-45, S100, and Melan A. These markers generally are all negative in ASPS. Anti-TFE3 has been shown to be highly specific and sensitive for ASPS.
Reference Data
Protein Categories Cancer: Bladder, Cancer: Sarcoma, Growth Factors, Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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Referencia
Descripción
Cond.
Precio Sin IVA
TA312794
TFE3 Rabbit Polyclonal Antibody
 100ul