TET2 Antibody - N-terminal region
Referencia OAGA07120
embalaje : 100ul
Marca : Aviva Systems Biology
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TET2 Antibody - N-terminal region (OAGA07120)
| Datasheets/Manuals | Printable datasheet for TET2 Antibody - N-terminal region (OAGA07120) |
|---|
| Predicted Species Reactivity | Human|Mouse |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | CHIP|ICC|IF|IHC-P|IP|WB |
| :: | Positive Controls: 293T, A431, HeLa, HepG2, DDDDK-human, TET2-transfected 293T |
| Reconstitution and Storage | -20°C or -80°C|2°C to 8°C |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human TET2. The exact sequence is proprietary. |
| Purification | Affinity Purified |
| Concentration | 1.35 mg/ml |
| Application Info | CHIP: Assay-dependent dilution ICC/IF: 1:100~1,000 IHC-FFPE: 1:100~1,000 IP: 1:100~500 WB: 1:500~10,000 Optimal dilutions should be determined by the end user. |
| Gene Symbol | TET2 |
|---|---|
| Gene Full Name | tet methylcytosine dioxygenase 2 |
| Alias Symbols | IMD75, KIAA1546, MDS, methylcytosine dioxygenase TET2, probable methylcytosine dioxygenase TET2, ten-eleven translocation 2, tet oncogene family member 2. |
| NCBI Gene Id | 54790 |
| Protein Name | Methylcytosine dioxygenase TET2 |
| Description of Target | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
| Uniprot ID | Q6N021 |
| Protein Accession # | NP_001120680.1 |
| Nucleotide Accession # | NM_001127208.2 |
| Molecular Weight | 224 kDa |
