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> T Cell Receptor (TCR) alpha/beta (alpha chain) Mouse Monoclonal Antibody [Clone ID: 3A8]

T Cell Receptor (TCR) alpha/beta (alpha chain) Mouse Monoclonal Antibody [Clone ID: 3A8]

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Referencia SM1230P

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T Cell Receptor (TCR) alpha/beta (alpha chain) Mouse Monoclonal Antibody [Clone ID: 3A8]

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SKU
SM1230P
T Cell Receptor (TCR) alpha/beta (alpha chain) mouse monoclonal antibody, clone 3A8, Purified
Size:
100 ug 50 ug
Conjugation:
Unconjugated
 

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Specifications
Product Data
Clone Name 3A8
Application IHC, IP
Recommended Dilution Immunoprecipitation.
Immunohistochemistry on Frozen Sections.
Reactivity Human
Antibody Host Mouse
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody clone 3A8 reacts with the alpha chain constant region found on all alpha/beta TCR bearing T-lymphocytes.
It reacts with 92-98% of all CD3 + peripheral blood lymphocytes.
Negative Species: Mouse, Rat.
Buffer PBS
State: Liquid purified IgG fraction
Stabilizer: 0.5% BSA
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Store undiluted at 2-8°C. DO NOT FREEZE! This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Database Link
Background T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.
Synonyms TCRA, TCRB, T-Cell Receptor alpha, T-Cell Receptor beta, T-Cell Receptor alpha beta
Reference Data
Protein Categories Membrane Proteins
Product Manuals
FAQs
  • Antibody and Western Standard
SDS
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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