RUNX1 Antibody - middle region : HRP
Referencia P100746_P050-HRP
embalaje : 100ul
Marca : Aviva Systems Biology
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RUNX1 Antibody - middle region : HRP (P100746_P050-HRP)
| Datasheets/Manuals | Printable datasheet for anti-RUNX1 (P100746_P050-HRP) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit |
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| Product Format | Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | HRP: Horseradish Peroxidase |
| Application | WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human RUNX1 |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: HPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSI |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-RUNX1 (P100746_P050-HRP) antibody is Catalog # AAP31063 (Previous Catalog # AAPP01801) |
| Sample Type Confirmation | There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 |
| Reference | Takeshita,M., (2008) Leukemia 22 (6), 1241-1249 |
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| Gene Symbol | RUNX1 |
| Gene Full Name | Runt-related transcription factor 1 |
| Alias Symbols | AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, CBF2alpha, AML1-EVI-1, PEBP2alpha |
| NCBI Gene Id | 861 |
| Protein Name | Runt-related transcription factor 1 |
| Description of Target | Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. RUNX1 is the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with severaltypes of leukemia. Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | Q01196 |
| Protein Accession # | NP_001001890 |
| Nucleotide Accession # | NM_001001890 |
| Protein Size (# AA) | 453 |
| Molecular Weight | 49kDa |
| Protein Interactions | YAP1; UBC; HDAC11; SOX2; SMAD3; CTBP1; RUNX1; FOXP3; NCOR2; MYC; NOTCH1; UXT; CTBP2; KAT6A; PML; CREBBP; CBFB; PRMT1; HLA-DMA; HDAC2; HDAC1; CBFA2T3; RUNX1T1; CBFA2T2; ELAVL1; DNMT1; SPEN; RBM14; KMT2A; COPRS; HDAC3; TAL1; CDK1; SMARCC1; SMARCB1; SMARCA4; |
