Recombinant Murine GM-CSF Protein (HEK293, C-His)

Biological Activity

Recombinant Murine GM-CSF Protein is a hematopoietic growth factor that can promote the development of neutrophils and macrophages, and promote the proliferation and development of early erythroid megakaryocytes and eosinophilic progenitors. GM-CSF inhibits the migration of neutrophils and enhances the functional activity of mature terminal cells.

Depends on stimulating mouse FDC-P1 cell proliferation in a dose-dependent manner, the expected ED50 is ≤0.05 ng/ml, corresponding to specific activity ≥2×10⁷ IU/mg.

Product Citations

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  Adv Mater. 2024 Jan;36(2):e2307263.

  Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo-Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment
  Recombinant Murine GM-CSF Protein (HEK293, C-His) purchased from AbMole

Chemical Information

Solubility (25°C)	Reconstitute the lyophilized powder in ddH2O or PBS at 100 μg/ml
Storage	Stored at ≤ -20°C, stable for one year after receipt

References

[1] Pravin Yeapuri, et al. J Control Release. Development of an extended half-life GM-CSF fusion protein for Parkinson's disease

[2] Michael Dougan, et al. Immunity. GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

[3] E Reali, et al. Vaccine. Comparative studies of Avipox-GM-CSF versus recombinant GM-CSF protein as immune adjuvants with different vaccine platforms

[4] J C Schuh, et al. Toxicol Pathol. Development of a recombinant growth factor and fusion protein: lessons from GM-CSF

[5] C Wiltschke, et al. Immunobiology. Murine recombinant GM-CSF-driven rat bone marrow cell differentiation and factors suppressing cell proliferation