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> Ptger2 Rabbit Polyclonal Antibody

Ptger2 Rabbit Polyclonal Antibody

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Referencia TA329010

embalaje : 50ul

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Ptger2 Rabbit Polyclonal Antibody

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SKU
TA329010
Rabbit polyclonal Anti-Prostanoid EP2 Receptor (extracellular)
Size:
50 ul
Conjugation:
Unconjugated
 

View other "Ptger2 or NM_031088" antibodies

Specifications
Product Data
Application FC, IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)DETSSRKEKWDLR, corresponding to amino acid residues 287-299 of rat prostanoid EP2 receptor . 3rd extracellular loop.
Buffer Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Gene Name prostaglandin E receptor 2 (subtype EP2)
Database Link
Background Prostaglandin E2 (PGE2) is involved in a number of physiological and pathophysiological events in many tissues throughout the body. The physiological actions of PGE2 are mediated through its interaction with cell surface prostaglandin E receptors. There are three pharmacologically defined subtypes of the EP receptor, EP1, EP2, and EP3, and these subtypes are suggested to be different in their signal transduction. These receptors belong to the G-protein coupled receptor (GPCR) superfamily. Like all members they have seven transmembrane domains with extracellular N-terminal tail and intracellular C-terminus. The EP2 receptor is expressed in the vasculature, the gastrointestinal tract, kidney and also in the ciliary muscles in the eye. PGE2 is known to play a central role in the pathophysiology of inflammation in synergy with other proinflammatory mediators. PGE2 inhibits the function and the proliferation of T cells and the histamine release from mast cells by increasing the intracellular level of cAMP. EP2 subtype is thought to be in part responsible for vasodilation, oedema formation, hyperanalgesia, modulation of the immune system, and the breakdown of bone and cartilage associated with disorders such as rheumatoid arthritis.
Synonyms EP2
Reference Data
Product Manuals
FAQs
  • Antibody and Western Standard
SDS

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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Precio Sin IVA