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> Polymyxin B (Sulfate) [1405-20-5]

Polymyxin B (Sulfate) [1405-20-5]

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Referencia HY-A0248-5g

embalaje : 5g

Marca : MedChemExpress

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Descripciòn

Polymyxin B Sulfate is an antibiotic. Polymyxin B Sulfate inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B Sulfate neutralizes the effect of endotoxin. Polymyxin B Sulfate induces bacterial death by increasing its permeability. Polymyxin B Sulfate is used in endotoxemia research[1][2][3][4].

In Vitro

Polymyxin B (10 μg/mL, 6 h) Sulfate decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].
Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polymyxin B Sulfate Related Antibodies
In Vivo

Polymyxin B (0.5-120 mg/kg; s.c.) Sulfate shows antibacterial activities in thigh or lung infection mouse model[2].
Polymyxin B (2 mg/kg, s.c.) Sulfate shows potent in mouse bactericidal effect against E. coli strain IH3080[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
Administration: S.c.
Result: Showed antibacterial activities for three K. pneumoniae strains.
Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
Dosage: 2 mg/kg
Administration: S.c.
Result: Decreased the bacterial count in a dose dependent manner.
Peso molecular

1199.75 (average)

No. CAS
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source

Bacillus polymyxa
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 116.67 mg/mL (Need ultrasonic)

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