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> PEG300 [25322-68-3]

PEG300 [25322-68-3]

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PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.

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PEG300 Estructura química

PEG300 Estructura química

No. CAS : 25322-68-3

This product is a controlled substance and not for sale in your territory.

Based on 61 publication(s) in Google Scholar

Other Forms of PEG300:

  • PEG400 In-stock
  • PEG1500 In-stock
  • PEG200 In-stock
  • PEG500 In-stock
  • PEG3000 In-stock
Descripciòn

PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1][2].

In Vitro

The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PEG300 Related Antibodies
In Vivo

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. When administered orally, the highest concentration of PEG300 can reach up to 90%[4][5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

300.00

No. CAS

25322-68-3
Appearance

Liquid

Color

Colorless to light yellow

SMILES

05OCCO05.5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (333.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (166.67 mM)

*"≥" means soluble, but saturation unknown.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: ≥97.0%

COA (241 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. J.Billingham, et al. Adsorption of polyamine, polyacrylic acid and polyethylene glycol on montmorillonite: An in situ study using ATR-FTIR. Volume 14, Issue 1, March 1997, Pages 19-34.

    [2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12.  [Content Brief]

    [3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21.  [Content Brief]

    [4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.  [Content Brief]

    [5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.  [Content Brief]

  • [1]. J.Billingham, et al. Adsorption of polyamine, polyacrylic acid and polyethylene glycol on montmorillonite: An in situ study using ATR-FTIR. Volume 14, Issue 1, March 1997, Pages 19-34.

    [2]. Lee CC, et al. Structural basis of polyethylene glycol recognition by antibody. J Biomed Sci. 2020 Jan 7;27(1):12.

    [3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21.

    [4]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.

    [5]. Ellen Weisberg, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3333 mL 16.6667 mL 33.3333 mL 83.3333 mL
5 mM 0.6667 mL 3.3333 mL 6.6667 mL 16.6667 mL
10 mM 0.3333 mL 1.6667 mL 3.3333 mL 8.3333 mL
15 mM 0.2222 mL 1.1111 mL 2.2222 mL 5.5556 mL
20 mM 0.1667 mL 0.8333 mL 1.6667 mL 4.1667 mL
25 mM 0.1333 mL 0.6667 mL 1.3333 mL 3.3333 mL
30 mM 0.1111 mL 0.5556 mL 1.1111 mL 2.7778 mL
40 mM 0.0833 mL 0.4167 mL 0.8333 mL 2.0833 mL
50 mM 0.0667 mL 0.3333 mL 0.6667 mL 1.6667 mL
60 mM 0.0556 mL 0.2778 mL 0.5556 mL 1.3889 mL
80 mM 0.0417 mL 0.2083 mL 0.4167 mL 1.0417 mL
100 mM 0.0333 mL 0.1667 mL 0.3333 mL 0.8333 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PEG300 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEG30025322-68-3Polyethylene glycol 300PEG 300PEG-300Polyethylene glycol300Polyethylene glycol-300Biochemical Assay ReagentsimmunogenicbiocompatiblepolymergastrointestinalmarkerInhibitorinhibitorinhibit

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