PDGFB antibody - N-terminal region
Referencia ARP58509_P050
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PDGFB Antibody - N-terminal region (ARP58509_P050)
| Datasheets/Manuals | Printable datasheet for anti-PDGFB (ARP58509_P050) antibody |
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| Tested Species Reactivity | Human |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Sheep |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB, IHC |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human PDGFB |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: NRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGD |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-PDGFB (ARP58509_P050) antibody is Catalog # AAP58509 (Previous Catalog # AAPP34718) |
| Sample Type Confirmation | There is BioGPS gene expression data showing that PDGFB is expressed in HEK293T |
| Subunit | B |
| Reference | Chadjichristos,C.E., (2008) Circ. Res. 102 (6), 653-660 |
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| Gene Symbol | PDGFB |
| Gene Full Name | Platelet-derived growth factor beta polypeptide |
| Alias Symbols | SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2 |
| NCBI Gene Id | 5155 |
| Protein Name | Platelet-derived growth factor subunit B |
| Description of Target | PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene. |
| Uniprot ID | P01127 |
| Protein Accession # | NP_002599 |
| Nucleotide Accession # | NM_002608 |
| Protein Size (# AA) | 241 |
| Molecular Weight | 27kDa |
| Protein Interactions | COL6A1; COL5A1; COL4A1; COL3A1; COL2A1; COL1A2; COL1A1; LYVE1; NRP1; ADIPOQ; MDFI; PDAP1; ART1; PDGFB; HRAS; THBS1; PDGFRA; PDGFRB; HSPG2; LRP1; A2M; SPARC; |
