Pam3CSK4 TFA (112208-00-1 free base) [112208-01-2]
Referencia NB-64-67732-5mg
embalaje : 5mg
Marca : Neo Biotech
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Pam3CSK4 TFA (112208-00-1 free base) (Synonyms: Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA)
Catalog No. TP1067 Copy Product Info
Purity: 99.01%
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.
Pam3CSK4 TFA (112208-00-1 free base)
Copy Product InfoSynonyms Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.
Cas No. 112208-01-2
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Purity:99.01%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2. |
| Targets&IC50 | TLR1:0.47 ng/mL (EC50), TLR2:0.47 ng/mL (EC50) |
| In vitro | Pretreatment with high doses of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (>25 μg/ml) improves the antimicrobial activity of neutrophils generated directly from mouse bone marrow. [3] |
| In vivo | METHODS: Mice were intraperitoneally (ip) injected with Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (5 mg/kg) from postnatal day (PND) 3 to 11. Pups were killed at PND12 or PND53, and brains, spleens, and livers were collected and weighed. Brain sections were stained for markers of brain injury. RESULTS Nine days after administration of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA), mice showed a decrease in gray matter volume, white matter volume in the molecular layer of the forebrain and cerebellum, and an increase in spleen and liver weight at PND12. [1] |
| Synonyms | Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA |
| Molecular Weight | 1852.33 |
| Formula | C87H159F9N10O19S |
| Cas No. | 112208-01-2 |
| Smiles | O=C(N[C@@H](CCCCN)C(=O)O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC)CSCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O |
| Relative Density. | no data available |
| Sequence | {Pam3Cys}-Ser-Lys-Lys-Lys-Lys |
| Sequence Short | Pam3C-SKKKK |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 16.67 mg/mL (9 mM), Sonication and heating are recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
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