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> Oct4 (POU5F1) (NM_002701) Human Recombinant Protein

Oct4 (POU5F1) (NM_002701) Human Recombinant Protein

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Referencia TP762703

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Oct4 (POU5F1) (NM_002701) Human Recombinant Protein

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SKU
TP762703
Purified recombinant protein of Human POU class 5 homeobox 1 (POU5F1/OCT4), transcript variant 1, 1Met-160Leu, with N-terminal His tag, expressed in E.coli, 50ug
 

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Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region (1Met-160Leu) of OCT4
Tag N-His
Predicted MW 18.6 kDa
Concentration >0.05 ug/ul as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, 150mM NaCl, 10% glycerol, pH8.0, 1% SKL
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002692
Locus ID 5460
UniProt ID Q01860 D2IYK3
Cytogenetics 6p21.33
RefSeq Size 1417
RefSeq ORF 1080
Synonyms Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4
Summary This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. provided by RefSeq, Oct 2013
Protein Categories ADC Targets, Cytokines, Intracellular Proteins, Transciption Factors
Protein Families Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Transcription Factors
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