Nattokinase [133876-92-3]
Referencia M2121-10mg
embalaje : 10mg
Marca : AbMole Bioscience
Contact local distributor :
Teléfono : +1 850 650 7790
All AbMole products are for research use only, cannot be used for human consumption.
Quality Control & Documentation
Biological Activity
Nattokinase is an enzyme extracted and purified from a Japanese food called nattō. Nattokinase is a serine protease of the subtilisin family. It exhibits a strong fibrinolytic activity. A 2009 study showed that nattokinase may be effective in catabolism of toxic amyloid fibrils associated with Alzheimer's Disease, as well as the insulin fibrils associated with diabetes and the prion peptide fibrils associated with prion diseases.
Product Citations
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Frontiers in Plant Science. 2025 Sep 10; .
Transient expression of fulllength and mature nattokinase in Nicotiana benthamiana reveals early necrosis from full-length form and functional activity of the mature enzyme
Nattokinase purchased from AbMole -
Transbound Emerg Dis. 2025 Mar 03; .
Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases
Nattokinase purchased from AbMole -
J Diabetes. 2023 Jul 4.
Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy
Nattokinase purchased from AbMole -
Invest Ophthalmol Vis Sci. 2021 May 3;62(6):25.
Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation
Nattokinase purchased from AbMole
Protocol (for reference only)
| Cell Experiment | |
|---|---|
| Cell lines | 2.5% (w/v) brain homogenate |
| Preparation method | Then, proteinase K-treated samples were boiled at 95°C for 5 min and treated with nattokinase (Abmole, Houston, USA) and lumbrokinase for 5 h to evaluate the PrPSc degradation ability of these enzymes. |
| Concentrations | Not mentioned |
| Incubation time | 5 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J mice |
| Formulation | 1 µM dissolved in 10% [v/v] DMSO in PBS |
| Dosages | 5 µM |
| Administration | Intravenous injection |
Chemical Information
| Molecular Weight | 463.5 |
| Formula | C23H28ClN3O5 |
| CAS Number | 133876-92-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
References
[1] Cho YH, et al. N Biotechnol. Production of nattokinase by batch and fed-batch culture of Bacillus subtilis.