CD3 Unconjugated
Catalog #
Size
| Conjugation | Unconjugated |
|---|---|
| Antigen | CD3 |
| Clone | OKT3 |
| Isotype | IgG2a, k |
| Applications | FC |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Immunogen | Human peripheral blood lymphocytes |
| Format | 0.09% sodium azide, PBS pH 7.2 |
| Storage | 2-8°C |
| Status | RUO |
Description:
CD3ε is a 20kD chain, which together with CD3λ, CD3δ, and CD3ζ, and a T cell receptor(α/β or γ/σ) form the CD3/T-cell receptor complex. It is a specific marker for T lymphocytes, NK T cells, and some thymocytes. Crosslinking of TCR initiates an intracellular signaling cascade resulting in cellular activation and proliferation. The OKT3 has been reported to have potent immunosuppressive properties in vivo and has been proved effective in the treatment of renal, heart, and liver allograft rejection..
CD3ε is a 20kD chain, which together with CD3λ, CD3δ, and CD3ζ, and a T cell receptor(α/β or γ/σ) form the CD3/T-cell receptor complex. It is a specific marker for T lymphocytes, NK T cells, and some thymocytes. Crosslinking of TCR initiates an intracellular signaling cascade resulting in cellular activation and proliferation. The OKT3 has been reported to have potent immunosuppressive properties in vivo and has been proved effective in the treatment of renal, heart, and liver allograft rejection..