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> MCP1 (CCL2) (NM_002982) Human Recombinant Protein

MCP1 (CCL2) (NM_002982) Human Recombinant Protein

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Referencia TP723718

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MCP1 (CCL2) (NM_002982) Human Recombinant Protein

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SKU
TP723718
Purified recombinant protein of Human chemokine (C-C motif) ligand 2 (CCL2 / MCP-1)
 

Other products for "MCP1 or NM_002982"

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  • Lentiviral
  • AAV
  • CRISPR
  • RNAi
  • Proteins
  • Antibodies
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Human MCP1, the region of Gln24-Thr99, from gene Accession# NM_002982
Tag Tag Free
Predicted MW 8.7 kDa
Concentration lot specific
Purity Purity is >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 10 mM NaHPO4 pH 7.2, 0.15M NaCl
Bioactivity The ED50 is 6-15 ng/ml, corresponding to a specific activity of 1.6-0.6 x 10^5 units/mg, determined by the dose dependent chemoattraction of THP-1 cells
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002973
Locus ID 6347
UniProt ID P13500
Cytogenetics 17q12
RefSeq Size 760
RefSeq ORF 297
Synonyms GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF
Summary This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. provided by RefSeq, Aug 2020
Protein Categories Chemokines, Cytokines, Growth Factors, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway
FAQs
  • Protein FAQs
SDS
SKU Description Size
PH302180 CCL2 MS Standard C13 and N15-labeled recombinant protein (NP_002973) 10 ug
LC401046 Lyophilized CCL2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
LY401046 Transient overexpression lysate of chemokine (C-C motif) ligand 2 (CCL2) (as WB positive control) 100 ug
TP302180 Recombinant protein of human chemokine (C-C motif) ligand 2 (CCL2), 20 µg 20 ug
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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