Lauramine oxide [1643-20-5]
Referencia NB-64-10605-1g
embalaje : 1g
Marca : Neo Biotech
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Teléfono : +1 850 650 7790
Lauramine oxide (Synonyms: Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide)
Catalog No. T20936 Copy Product Info
Purity: 99.71%
Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.
Lauramine oxide
Copy Product InfoSynonyms Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide
Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.
Cas No. 1643-20-5
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
Lauramine oxide AI Summary
Lauramine oxide is a multifaceted bioactive molecule with significant inhibitory effects against various targets. It notably inhibits Oleoyl-CoA Synthetase (OSC) with an IC50 value of 2150.0 nM and demonstrates an 84.0% inhibitory effect at a concentration of 20 µM, underscoring its potency in this pathway. Additionally, it shows inhibitory activity on anti-DNP-IgE-induced degranulation in rat RBL2H3 cells, with a 40.0% inhibition rate observed at 25 µM after 30 minutes. The compound also interacts with several signaling pathways: it acts as an agonist of the retinoid X receptor alpha and the antioxidant response element (ARE) signaling pathway through Nrf2-dependent transcriptional activity, and an antagonist of androgen and glucocorticoid receptor signaling. Furthermore, it serves as an activator of both rat and human pregnane X receptor (PXR) signaling pathways. Moreover, in assays involving human OSC expressed in Saccharomyces cerevisiae, Lauramine oxide exhibited complete inhibition (100.0%) at 20 µM in one assay, 85.0% inhibition in another, and an IC50 value of 6310.0 nM. These diverse bioactivities highlight its potential as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins. |
| Synonyms | Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide |
| Molecular Weight | 229.4 |
| Formula | C14H31NO |
| Cas No. | 1643-20-5 |
| Smiles | C(CCCCCCCCC)CCN(C)(C)=O |
| Relative Density. | 0.996 g/cm3 at 20℃ |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | DMSO: 2.3 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||