Latent TGF beta 1 Protein, Human, Recombinant (His)
Referencia NB-64-56299-5ug
embalaje : 5ug
Marca : Neo Biotech
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Latent TGF beta 1 Protein, Human, Recombinant (His)
(Synonyms: transforming growth factor, β1, transforming growth factor, beta 1, TGF-β1, TGFβ, TGF-beta 1, TGFbeta, TGFB, TGF β1, LAP, DPD1, CED) Copy Product InfoSynonyms: transforming growth factor, β1, transforming growth factor, beta 1, TGF-β1, TGFβ, TGF-beta 1, TGFbeta, TGFB, TGF β1, LAP, DPD1, CED
Catalog No. TMPY-01133 Copy Product Info
Purity: 99.5%
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.5%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its binding ability in a functional ELISA. Immobilized Human TGF beta 1 His at 2 μg/ml (100 μl/well) can bind Human TGFBR2 His & hFc , the EC50 of Human TGFBR2 His & hFc is 5-35 ng/mL. |
| Description | Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P01137 |
| Construction | A DNA sequence encoding the full length of human TGFβ1 (NP_000651.3) (Met 1-Ser 390) was fused with a C-terminal polyhistidine tag. Predicted N terminal: Leu 30 & Ala 279 |
| Protein Purity | > 95 % as determined by SDS-PAGE  |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | transforming growth factor, β1, transforming growth factor, beta 1, TGF-β1, TGFβ, TGF-beta 1, TGFbeta, TGFB, TGF β1, LAP, DPD1, CED |
| Research Background | TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 42.4 kDa (predicted); 16, 38 and 55 kDa (reducing condition, due to glycosylation); 110 kDa (non-reduced condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Keywords
transforming growth factor, β 1transforming growth factor, b 1TGF-β 1TGF-b 1DPD-1DPD 1
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Related Tags: Latent TGF beta 1 Protein, Human, Recombinant (His) chemical structure | Latent TGF beta 1 Protein, Human, Recombinant (His) molecular weight
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