Defined substructure of the Re mutant of lipopolysaccharide (LPS). Strong activator (<10ng/ml) of toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.

Source:
Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant) [1] by a modification of the PCP extraction method [2,3], converted to the uniform sodium salt form [4] and dissolved in sterile pyrogen-free double distilled water.

Synonyms:
(3-Deoxy-D-manno-octulosonic acid)2-Lipid A

CAS No:
123621-04-5 (free base)

Molecular Formula:
C110H198N2Na4O39P2

Molecular Weight:
2326.70

Appearance:
Supplied as a sterile, ready-to-use clear, colorless solution in pyrogen-free double distilled water.

Purity:
Absence of detectable protein or DNA contaminants with agonistic TLR activity.

Concentration:
~0.5mg/ml

Storage and Stability:
May be stored at 4°C. Do not freeze. Stable for 6 months after receipt.

Handling:
Keep sterile. Do not ingest. Wear gloves and mask. Avoid contact through all modes of exposure. Avoid inhalation and prevent from entering the bloodstream. Use must be restricted to qualified
personnel.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: 
All products should be handled by qualified personnel only, trained in laboratory procedures.