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> Insulin Protein, Human, Recombinant

Insulin Protein, Human, Recombinant

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Insulin Protein, Human, Recombinant

(Synonyms: MODY10, IRDN, insulin, INS, ILPR, IDDM2, IDDM1, IDDM) Copy Product Info

Synonyms: MODY10, IRDN, insulin, INS, ILPR, IDDM2, IDDM1, IDDM

Catalog No. TMPY-00395 Copy Product Info
Purity: 97.2%
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Other Forms of Insulin Protein, Human, Recombinant:
Insulin (human)
Insulin(cattle)
Insulin B (22-30)
Insulin B (20-30)
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:97.2%
Appearance:Lyophilized powder
Color:White
Contact us for more batch information

Product Introduction

Bioactivity
Bioactivity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.2-1 µg/mL.
Description
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Species
Human
Expression System
P. pastoris (Yeast)
TagTag Free
Accession NumberP01308
ConstructionA DNA sequence encoding human insulin B chain (P01308)(Phe25-Lys53) and human insulin A chain (P01308)(Gly90-Asn110) was expressed with a linker AAK. Predicted N terminal: Phe
Protein Purity
> 95% as determined by SDS-PAGE
Insulin Protein, Human, Recombinant
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionReconstituted with sterile deionized water to 0.13 mg/mL. Reconstitution conditions may vary depending on the lot.
SynonymsMODY10, IRDN, insulin, INS, ILPR, IDDM2, IDDM1, IDDM
Research Background
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10. A multitude of mutant alleles with phenotypic effects has been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes mellitus, maturity-onset diabetes of the young type 10, and hyperproinsulinemia.
Chemical Properties
Molecular Weight7.1 kDa (predicted); 6 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

MODY-10MODY 10IDDM-2IDDM-1IDDM 2IDDM 1
Related Tags: Insulin Protein, Human, Recombinant chemical structure | Insulin Protein, Human, Recombinant molecular weight