Indolelactic acid [1821-52-9]

Biological Activity

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity. Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells. Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells.

Chemical Information

Molecular Weight	205.21
Formula	C11H11NO3
CAS Number	1821-52-9
Solubility (25°C)	DMSO 90 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Martin F Laursen, et al. Nat Microbiol. Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

[2] Yaping Shao, et al. Mol Neurodegener. Comprehensive metabolic profiling of Parkinson's disease by liquid chromatography-mass spectrometry

[3] Ye-Ting Zou, et al. J Ethnopharmacol. Protective effects of Poria cocos and its components against cisplatin-induced intestinal injury

[4] J A Leal, et al. Can J Microbiol. The production of indolelactic acid from L-tryptophan by species of Phytophthora

[5] T K Narayanan, et al. Antimicrob Agents Chemother. Beta-indoleethanol and beta-indolelactic acid production by Candida species: their antibacterial and autoantibiotic action