embalaje : 100mg
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Synonyms: IC Green, Foxgreen, Cardiogreen
| Description | Indocyanine green (Cardiogreen) is a low toxicic fluorescent agent, is a tricarbocyanine dye,has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. |
| In vitro | Cardiogreen(ICG-PDT) at concentrations 1000μg/mL, induced the significant expression of BAX in HGF cells; however, the laser irradiation as well as ICG showed no significant effects on the expression of these genes. Treatment with ICG alone, laser irradiation and ICG-PDT caused no observable BCL-2 gene expression changes between the tested and control groups. |
| Synonyms | IC Green, Foxgreen, Cardiogreen |
| Animal Research | Indocyanine green is used to detect the distribution of oral polysaccharide nanoemulsions Operation steps: a. Dissolve indocyanine green in polysaccharide aqueous solution and then add to nanoemulsion to form a complex (the final concentration of indocyanine green in both solutions is 0.05 mg/mL); b. After oral administration of the complex, mice were fasted for 4 hours and then placed in a real-time imaging device to observe the distribution of fluorescence in vivo. Cell experiment operation steps: a. Add indocyanine green at a final concentration of 1mg/mL to serum-free hepatocyte culture medium and culture at 37℃ for 1 hour; b. Remove serum-free culture medium and wash cells three times with PBS; c. Examine and image cells under a microscope. The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands. |
| Molecular Weight | 774.96 |
| Formula | C43H47N2NaO6S2 |
| Cas No. | 3599-32-4 |
| Smiles | [Na+].CC1(C)\C(=C/C=C/C=C/C=C/C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c2ccc3ccccc3c12 |
| Relative Density. | no data available |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (12.9 mM), Sonication is recommended. DMSO: 21.67 mg/mL (27.96 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (2.58 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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