Human NACHT, LRR and PYD domains-containing protein 4, NLRP4 ELISA Kit
Referencia MBS9339665-96
embalaje : 96-Strip-Wells
Marca : MyBiosource
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Teléfono : +1 850 650 7790
NLR Family, Pyrin Domain Containing 4 (NLRP4) ELISA Kit for Human
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9339665Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of NLRP4 (hereafter termed "analyte") in… More details
Product Overview
Online Datasheet in PDFProduct Name
NLR family, pyrin domain containing 4 (NLRP4), ELISA Kit
Full Product Name
Human NACHT, LRR and PYD domains-containing protein 4, NLRP4 ELISA Kit
Product Gene Name
NLRP4 elisa kit
Product Synonym Names
Human NACHT; LRR and PYD domains-containing protein 4 (NLRP4) ELISA kit; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2; NACHT; LRR and PYD containing protein 4; NACHT; leucine rich repeat and PYD containing 4; PAAD and NACHT-containing protein 2; PYRIN-containing APAF1; NLR family; pyrin domain containing 4
Species Reactivity
Human
Assay Type
Quantitative Sandwich
Detection Range
0.625ng/ml-20ng/ml
Sensitivity
0.1ng/ml
Preparation and Storage
Store all reagents at 2-8 degree C
Other Notes
Small volumes of NLRP4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for NLRP4 purchase
MBS9339665 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NLR family, pyrin domain containing 4 (NLRP4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NLRP4. The ELISA analytical biochemical technique of the MBS9339665 kit is based on NLRP4 antibody-NLRP4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NLRP4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NLRP4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Additional Details
NCBI/Uniprot data below describe general gene information for NLRP4. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 4
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 4
NCBI Official Symbol
NLRP4
NCBI Official Synonym Symbols
CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 4
UniProt Synonym Protein Names
Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP4
UniProt Synonym Gene Names
NALP4; PAN2; PYPAF4; RNH2; CT58; PAN2; PYPAF4
UniProt Entry Name
NALP4_HUMAN
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 4; cancer/testis antigen 58; ribonuclease inhibitor 2; PAAD and NACHT-containing protein 2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; NACHT, LRR and PYD containing protein 4; NACHT, leucine rich repeat and PYD containing 4; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4
NCBI Summary for NLRP4
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Show more UniProt Comments for NLRP4
NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: cytosol
Molecular Function: ATP binding
Biological Process: regulation of interferon type I production; positive regulation of interferon type I production; innate immune response; inflammatory response
Show more Protein type: Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: cytosol
Molecular Function: ATP binding
Biological Process: regulation of interferon type I production; positive regulation of interferon type I production; innate immune response; inflammatory response
Research Articles on NLRP4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with NLRP4 elisa kit
| Reference Product | PubMed Publications |
|---|---|
| NLRC4 elisa kit | >3 publications with NLRP4 and NLRC4 |
| CHUK elisa kit | >1 publications with NLRP4 and CHUK |
Pathways associated with NLRP4 elisa kit
| Products by Pathway | Pathway Diagram |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway antibodies | TNF-alpha/NF-kB Signaling Pathway Diagram |
Organs/Tissues associated with NLRP4 elisa kit
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >1 publications with NLRP4 and Blood |
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