Human IL-3 protein, His tag (Animal-Free)
Referencia MBS9719008-0,02mg
embalaje : 0.02mg
Marca : MyBiosource
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Fig.SDS-PAGE analysis of Human IL-3 protein, His tag
IL-3 Human Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9719008Description: Recombinant Human IL-3 protein expressed in HEK293 Cells.Background: Human interleukin-3 (hIL-3) is a therapeutically important cytokine involved in the maturation and differentiation of various cells of the immune system. IL-3 predominantly… More details
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Product Overview
Product Name
IL-3, Recombinant Protein
Full Product Name
Human IL-3 protein, His tag (Animal-Free)
Product Gene Name
IL-3 recombinant protein
Product Synonym Names
Hematopoietic growth factor; IL3; IL-3; IL-3MGC79398; interleukin 3 (colony-stimulating factor; multiple); interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; MCGFMGC79399; MULTI-CSF; multilineage-colony-stimulating factor; Multipotential colony-stimulating factor; P-cell stimulating factor; P-cell-stimulating factor
Sequence
Met1-Phe15 2
Host
HEK 293 Cells
Form/Format
Lyophilized from sterile PBS, pH7.4.
Purity/Purification
>95% as determined by SDS-PAGE
Preparation and Storage
Lyophilized human IL3 protein product should be stored desiccated below -18 degree C. Upon reconstitution, the protein should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
17,233 Da
OMIM
147740
Endotoxin
< 1 EU per ug of the protein as determined by the LAL method.
Protein Construction
Amino acid sequence derived from human IL3 protein (NP_000579.2, Met1-Phe152) was expressed with a polyhistidine tag at the C-terminus.
Protein Length
The recombinant human IL-3 protein consists of 140 amino acids and predicts a molecular mass of 16 kD.The apparent molecular mass of the human IL-3 is approximately 17-35kDa in SDS-PAGE under reducing conditions due to glycosylation.
Usage Notes
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized human IL-3 protein in the buffer which we provide not less than 100ug/mL, which can then be further diluted to other aqueous solutions.
Product Categories/Family for IL-3 recombinant protein
Cell Culture; Cytokines (Animal-Free)
Other Notes
Small volumes of IL-3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for IL-3 purchase
MBS9719008 is a recombinant protein targeting IL-3. Also known as Human IL-3 protein, His tag (Animal-Free). Host: HEK 293 Cells.
Additional Details
NCBI/Uniprot data below describe general gene information for IL-3. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-3
NCBI Official Synonym Full Names
interleukin 3
NCBI Official Symbol
IL3
NCBI Official Synonym Symbols
IL-3; MCGF; MULTI-CSF
UniProt Protein Name
Interleukin-3
UniProt Synonym Protein Names
Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
UniProt Gene Name
IL3
UniProt Synonym Gene Names
IL-3; MCGF
UniProt Entry Name
IL3_HUMAN
NCBI Protein Information
interleukin-3; P-cell stimulating factor; P-cell-stimulating factor; colony-stimulating factor, multiple; hematopoietic growth factor; mast cell growth factor; mast-cell growth factor; multilineage-colony-stimulating factor; multipotential colony-stimulat
NCBI Summary for IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for IL-3
IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.
Protein type: Cytokine; Oncoprotein; Apoptosis; Secreted; Secreted, signal peptide; Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity
Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; cell-cell signaling; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication
Show more Protein type: Cytokine; Oncoprotein; Apoptosis; Secreted; Secreted, signal peptide; Cell cycle regulation
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: extracellular space; extracellular region
Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity
Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; cell-cell signaling; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication
Research Articles on IL-3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with IL-3 recombinant protein
| Reference Product | PubMed Publications |
|---|---|
| IL2 recombinant protein | >84 publications with IL-3 and IL2 |
| IL5 recombinant protein | >50 publications with IL-3 and IL5 |
| JAK2 recombinant protein | >13 publications with IL-3 and JAK2 |
| IL7 recombinant protein | >10 publications with IL-3 and IL7 |
| CSF2RB recombinant protein | >10 publications with IL-3 and CSF2RB |
| IL3RA recombinant protein | >8 publications with IL-3 and IL3RA |
| FOS recombinant protein | >7 publications with IL-3 and FOS |
| GRB2 recombinant protein | >2 publications with IL-3 and GRB2 |
| PIK3CA recombinant protein | >1 publications with IL-3 and PIK3CA |
Pathways associated with IL-3 recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Asthma Pathway antibodies | Asthma Pathway Diagram |
| Asthma Pathway antibodies | Asthma Pathway Diagram |
| Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies | Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram |
| Calcium Signaling In The CD4+ TCR Pathway antibodies | Calcium Signaling In The CD4+ TCR Pathway Diagram |
| Cytokine Signaling In Immune System Pathway antibodies | Cytokine Signaling In Immune System Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Fc Epsilon RI Signaling Pathway antibodies | Fc Epsilon RI Signaling Pathway Diagram |
Diseases associated with IL-3 recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Bone Marrow Diseases Antibodies | >42 publications with IL-3 and Bone Marrow Diseases |
| Necrosis Antibodies | >30 publications with IL-3 and Necrosis |
| Disease Models, Animal Antibodies | >30 publications with IL-3 and Disease Models, Animal |
| Lung Diseases Antibodies | >24 publications with IL-3 and Lung Diseases |
| Inflammation Antibodies | >19 publications with IL-3 and Inflammation |
| Asthma Antibodies | >17 publications with IL-3 and Asthma |
| Anemia Antibodies | >12 publications with IL-3 and Anemia |
| Nervous System Diseases Antibodies | >10 publications with IL-3 and Nervous System Diseases |
| Brain Diseases Antibodies | >8 publications with IL-3 and Brain Diseases |
| Kidney Diseases Antibodies | >6 publications with IL-3 and Kidney Diseases |
Organs/Tissues associated with IL-3 recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Mixed Antibodies | >13 publications with IL-3 and Mixed |