HIF1AN Antibody
Referencia OAAN01303-50UL
embalaje : 50ul
Marca : Aviva Systems Biology
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Teléfono : +1 850 650 7790
HIF1AN Antibody
HIF1AN Antibody (OAAN01303)
| Datasheets/Manuals | Printable datasheet for HIF1AN Antibody (OAAN01303) |
|---|
| Predicted Species Reactivity | Human|Mouse|Rat |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Application | ELISA, ICC, IF, IP, WB |
| Reconstitution and Storage | Store at -20C. Avoid repeated freeze/thaw cycles. |
| Immunogen | HIF1AN/FIH1 |
| Purification | Affinity purified against immunogen |
| Application Info | WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200. IP: 1:50 - 1:200. CHIP: 1:20 - 1:100 |
| Gene Symbol | HIF1AN |
|---|---|
| Gene Full Name | hypoxia inducible factor 1 subunit alpha inhibitor |
| Alias Symbols | factor inhibiting HIF1, factor inhibiting HIF-1, FIH1, FIH-1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase. |
| NCBI Gene Id | 55662 |
| Protein Name | Hypoxia-inducible factor 1-alpha inhibitor |
| Description of Target | Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. |
| Uniprot ID | Q9NWT6 |
| Protein Accession # | NP_060372.2 |
| Nucleotide Accession # | NM_017902.2 |
| Molecular Weight | 41kda |