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Guaiacol [90-05-1]

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Referencia NB-64-04536-1mL

embalaje : 1mLx10mM(inDMSO)

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : Neo Biotech

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Contact local distributor :

Teléfono : +1 850 650 7790

Guaiacol (Synonyms: O-methylcatechol, o-methoxyphenol, 2-Methoxyphenol, 2-hydroxyanisole)

Catalog No. T1301 Copy Product Info

Purity: 99.95%

Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.

Guaiacol

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Synonyms O-methylcatechol, o-methoxyphenol, 2-Methoxyphenol, 2-hydroxyanisole

Cas No. 90-05-1

Batch Information

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Purity:99.95%

Appearance:Liquid

Color:Transparent

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COA HNMR HPLC

Product Introduction

Guaiacol AI Summary

Guaiacol exhibits a wide range of bioactivities across different biological systems. It has varying partition coefficients (logP), with higher values in solvents such as chloroform and benzene, suggesting its substantial lipophilicity, which could influence its bioavailability and distribution. The compound has a partition coefficient (logP) of 1.33 in the alkane/water system. It also exhibits inhibitory activity on the germination of Bacillus subtilis spores with an IC50 value of 6,310,000 nM and inhibitory effects on mouse recombinant iNOS and human recombinant 5-lipoxygenase. Guaiacol demonstrates activity against caspase-mediated apoptosis in mouse L1210 cells, anti-inflammatory effects in CD1 mice by inhibiting croton oil-induced ear edema, and inhibitory activity against human erythrocyte CA1 and CA2 esterase activities. It affects various enzymes and pathways, including histone lysine methyltransferase G9a, Nrf2-dependent DNA repair, and the androgen receptor signaling pathway. Additionally, it shows antibacterial and antifungal properties, with activity against Candida species, Staphylococcus aureus, and Bacillus subtilis, as well as moderate antiviral activity against SARS-CoV-2. Moreover, Guaiacol inhibits multiple enzyme activities and affects cell viability and proliferation in various human cell lines, showing potential cytotoxicity towards cancer cells with p53 mutations, and inhibits malaria parasite plastid death. Its antioxidant properties are evidenced by its capacity to scavenge DPPH free radicals. The compound also shows a deterrent effect against the cabbage looper Trichoplusia ni and has significant inhibitory effects on ligninolytic enzymes and mycelium growth in fungal species such as Lasiodiplodia theobromae and Botryosphaeria dothidea..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.
Synonyms	O-methylcatechol, o-methoxyphenol, 2-Methoxyphenol, 2-hydroxyanisole

Chemical Properties

Molecular Weight	124.14
Formula	C₇H₈O₂
Cas No.	90-05-1
Smiles	COC1=C(O)C=CC=C1
Relative Density.	1.129 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (2013.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.0554 mL	40.2771 mL	80.5542 mL	402.7711 mL
5 mM	1.6111 mL	8.0554 mL	16.1108 mL	80.5542 mL
10 mM	0.8055 mL	4.0277 mL	8.0554 mL	40.2771 mL
20 mM	0.4028 mL	2.0139 mL	4.0277 mL	20.1386 mL
50 mM	0.1611 mL	0.8055 mL	1.6111 mL	8.0554 mL
100 mM	0.0806 mL	0.4028 mL	0.8055 mL	4.0277 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.