GATSL1 Antibody - N-terminal region
Referencia OAAB14681
embalaje : 400µl
Marca : Aviva Systems Biology
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GATSL1 Antibody - N-terminal region (OAAB14681)
| Datasheets/Manuals | Printable datasheet for GATSL1 Antibody - N-terminal region (OAAB14681) |
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| Predicted Species Reactivity | Bovine|Human|Mouse|Rat|Xenopus |
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| Product Format | Liquid PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | IHC-P,WB |
| Additional Information | Cellular Location: Cytoplasm, cytosol Tissue Location: Widely expressed |
| Reconstitution and Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This GATSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-51 amino acids from the N-terminal region of human GATSL2. |
| Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Concentration | 0.26 mg/ml |
| Application Info | WB: 1:1000 IHC-P-Leica: 1:250 |
| Gene Symbol | CASTOR2 |
|---|---|
| Gene Full Name | cytosolic arginine sensor for mTORC1 subunit 2 |
| Alias Symbols | 2410008K03Rik, 7530428J21Rik, AW742413, castor2, cellular arginine sensor for mTORC1 protein 1, cellular arginine sensor for mTORC1 protein 2, cytosolic arginine sensor for mTORC1 subunit 1, cytosolic arginine sensor for mTORC1 subunit 2, Ga, Gat, Gats, Gats protein, GATS protein like 2, GATS protein like 3, GATS protein-like 1, GATS protein-like 1 L homeolog, GATS protein-like 2, GATS protein-like 3, GATS-like protein 1, GATS-like protein 2, GATS-like protein 3, GATS, stromal antigen 3 opposite strand, Gatsl1, Gatsl2, gatsl2.L, Gatsl3, opposite strand transcription unit to Stag3, Protein GATS, putative protein CASTOR 3, putative protein GATS, RGD1304774, STAG3 opposite strand transcript protein, STAG3OS, stromal antigen 3 opposite strand, XELAEV_18012794mg. |
| NCBI Gene Id | 352954|360969|446578|506974|652968|71962|729438|80909 |
| Protein Name | Cytosolic arginine sensor for mTORC1 subunit 1|Cytosolic arginine sensor for mTORC1 subunit 2|GATS-like protein 1 [Homo sapiens]|Putative protein CASTOR 3 |
| Description of Target | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.|Functions as a negative regulator of the TORC1 signaling pathway.|Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Uniprot ID | A6NHX0|Q0V8A3|Q5BJZ0|Q6DDW7|Q8CAB8|Q8NAP1|Q8WTX7|Q9CWQ8 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_001138535.1 |
| Molecular Weight | 36056 |