GABA-B Receptor Colorimetric Cell-Based ELISA Kit
Referencia OKAG00732
embalaje : One96-WellPlate
Marca : Aviva Systems Biology
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Teléfono : +1 850 650 7790
GABA-B Receptor Colorimetric Cell-Based ELISA Kit (OKAG00732)
| Datasheets/Manuals | Printable datasheet for GABA-B Receptor Colorimetric Cell-Based ELISA Kit (OKAG00732) |
|---|
| Predicted Species Reactivity | Homo sapiens|Human|Mouse|Rat |
|---|---|
| Product Format | 96-Well Microplate |
| Application | ELISA |
| ELISA Kit Detection Method | Colorimetric 450 nm |
| ELISA Kit Duration | 4.5 hours |
| ELISA Kit Range | At least 5000 cells/well |
| Additional Information | Dynamic Range: > 5000 Cells |
| :: | OMIM: 603540 UniGene: Hs.167017 |
| :: | Note: The product is for research use only, not for use in diagnostic or therapeutic procedures. |
| Reconstitution and Storage | 2°C to 8°C |
| Assay Info | Assay Type: Cell-Based Subtype: None Detection Method: Colorimetric 450 nm |
| Gene Symbol | GABBR1 |
|---|---|
| Gene Full Name | gamma-aminobutyric acid type B receptor subunit 1 |
| Alias Symbols | GABA-B receptor, R1 subunit, GABABR1, GABBR1-3, gamma-aminobutyric acid (GABA) B receptor, 1, gamma-aminobutyric acid type B receptor subunit 1, GB1, GPRC3A, seven transmembrane helix receptor. |
| NCBI Gene Id | 2550 |
| Protein Name | Gamma-aminobutyric acid type B receptor subunit 1 |
| Description of Target | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054). |
| Uniprot ID | Q9UBS5 |
