FITC-Dextran (MW 10000) [60842-46-8]

Biological Activity

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.

Product Citations

• 

  CNS Neurosci Ther. 2025 Jan 08;31(1):e70210.

  Rnf40 Exacerbates Hypertension-Induced Cerebrovascular Endothelial Barrier Dysfunction by Ubiquitination and Degradation of Parkin
  FITC-Dextran (MW 10000) purchased from AbMole

• 

  Aging (Albany NY). 2024 Mar 21;16(7):5905-5915.

  Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway
  FITC-Dextran (MW 10000) purchased from AbMole

Chemical Information

CAS Number	60842-46-8
Solubility (25°C)	Water 50 mg/mL
Storage	4°C, protect from light, dry, sealed

References

[1] Jizhu Li, et al. BMC Ophthalmol. Retro-orbital injection of FITC-dextran combined with isolectin B4 in assessing the retinal neovascularization defect

[2] Viki Raz Lepsky, et al. Biomolecules. FITC-Dextran Release from Cell-Embedded Fibrin Hydrogels

[3] Yangyang Xu, et al. J Neurosci Methods. Quantifying blood-brain-barrier leakage using a combination of evans blue and high molecular weight FITC-Dextran

[4] Anni Woting, et al. Nutrients. Small Intestinal Permeability and Gut-Transit Time Determined with Low and High Molecular Weight Fluorescein Isothiocyanate-Dextrans in C3H Mice

[5] Ida Eriksson, et al. Methods Mol Biol . Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells

[6] Reka Natarajan, et al. Curr Protoc Neurosci . Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability

[7] Reka Natarajan, et al. Curr Protoc Neurosci. Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability