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> EGFR Protein, Mouse, Recombinant (hFc)

EGFR Protein, Mouse, Recombinant (hFc)

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EGFR Protein, Mouse, Recombinant (hFc)

(Synonyms: Wa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik) Copy Product Info

Synonyms: Wa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik

Catalog No. TMPY-02675 Copy Product Info
EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.
Other Forms of EGFR Protein, Mouse, Recombinant (hFc):
EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (His)
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
EGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus, Recombinant (hFc)
EGFR Protein, Human, Recombinant (His)
EGFR Protein, Human, Recombinant (hFc)
EGFR Protein, Mouse, Recombinant (His)
EGFR Protein, Rat, Recombinant (His)
EGFR Protein, Canine, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
1.Immobilized Recombinant Mouse EGFR/HER1/ErbB1 Protein (Fc Tag) (Cat#TMPY-02675) at 2 μg/mL (100 μL/well) can bind Recombinant Human EGF/Epidermal Growth Factor Protein (Fc Tag), Biotinylated, the EC50 is 11.3 ng/mL (Routinely tested).
2.Immobilized Recombinant Mouse EGFR/HER1/ErbB1 Protein (Fc Tag) (Cat#TMPY-02675) at 2 μg/mL (100 μL/well) can bind Recombinant Mouse EGF/Epidermal Growth Factor Protein (Fc Tag), Biotinylated, the EC50is 1.5-4.5 ng/mL (QC tested).
Description
EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.
Species
Mouse
Expression System
HEK293 Cells
TagC-hFc
Accession NumberQ01279
ConstructionA DNA sequence encoding the extracellular domain of mouse EGFR (Q01279) (Met 1-Ser 647) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 25
Protein Purity
> 90 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsWa5, wa-2, wa2, Errp, Errb1, Erbb, epidermal growth factor receptor, AI552599, 9030024J15Rik
Research Background
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Chemical Properties
Molecular Weight96 kDa (predicted); 130 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

AI-552599AI 552599
Related Tags: EGFR Protein, Mouse, Recombinant (hFc) chemical structure | EGFR Protein, Mouse, Recombinant (hFc) molecular weight